Your GLP-1 shots might be doing the heavy lifting, but supplements are the besties keeping your energy, metabolism, and glow on point while your appetite does its disappearing act. You’re losing weight, which is amazing—but you’re also eating way less food, which means potentially way fewer nutrients. Your body still needs vitamins, minerals, protein, and support to function optimally, especially when you’re asking it to drop pounds while maintaining muscle, energy, and that “I’m thriving” glow. The supplement aisle is overwhelming and full of expensive promises that don’t deliver, so I’m cutting through the noise for you.
These are the only seven supplements for GLP-1 users you actually need—no snake oil, no pseudoscience, no $200 miracle powders. Just evidence-based picks that help you feel better, recover faster, and get more consistent results, all available on Amazon Prime because we’re busy people with lives to live. Supplements for GLP-1 users can help you feel better, recover faster, and get more consistent results when chosen strategically. Whether you’re on semaglutide, tirzepatide, or working with a telehealth provider like GobyMeds or OrderlyMeds, the right GLP-1 stack can make the difference between “I’m barely surviving this” and “I actually feel amazing.”
Why Supplements Matter on GLP-1s
Let’s talk about what’s actually happening in your body right now. When you’re on GLP-1 medications, your appetite drops significantly—that’s the point. But here’s the thing: your nutritional needs don’t drop with your appetite. Your body still requires vitamins, minerals, protein, and essential nutrients to run all its systems, heal tissues, produce hormones, maintain muscle mass, support your immune system, and keep your energy levels functional.
When your dinner is three bites and a dream, your body needs a little backup. You’re probably eating 40-60% less food than you used to, which means you’re also getting 40-60% fewer micronutrients from food sources. Even if you’re eating the most nutrient-dense meals possible, it’s genuinely difficult to get everything your body needs from 1,000-1,400 calories per day. This is where strategic supplements for GLP-1 gals become not just helpful, but necessary for feeling your best.
The benefits of adding supportive vitamins and minerals include:
- Sustained energy levels instead of the constant fatigue that plagues many GLP-1 users
- Better muscle preservation during weight loss (you want to lose fat, not muscle)
- Reduced side effects like nausea, constipation, and brain fog
- Improved sleep quality which directly impacts your weight loss results
- Stronger immune function so you don’t get sick every time your body is stressed
- Better skin, hair, and nail health because rapid weight loss can affect these noticeably
- Support for your metabolism to keep it running efficiently even in a calorie deficit
Think of supplements for GLP-1 as your insurance policy against nutrient depletion. They’re not magic pills that make weight loss faster (nothing ethical works that way), but they are foundational support that helps your body handle the metabolic changes you’re asking it to navigate.
Struggling with energy or weird cravings? Check out my post Managing Semaglutide Cravings and Energy Drops for the complete strategy on stabilizing your energy while eating less.
The 7 Best Supplements for GLP-1 Users (Amazon Finds + Science)
Okay, let’s get into the actual best supplements for GLP-1s that earn their spot in your routine. These are listed in order of priority—if you only do three, start with the first three. If you can swing the whole stack, even better.
1. Magnesium Glycinate – The Sleep & Muscle Savior
Magnesium is involved in over 300 biochemical reactions in your body, including muscle relaxation, energy production, sleep regulation, and stress management. Most people are already deficient, and when you add reduced food intake on GLP-1s, that deficiency can become significant. Low magnesium shows up as muscle cramps, poor sleep quality, anxiety, fatigue, and constipation (already a common GLP-1 side effect).
Why glycinate specifically: This form is highly absorbable and gentle on your stomach, unlike magnesium oxide which can cause digestive upset. Glycinate also has a calming effect that supports better sleep quality—and better sleep directly improves your weight loss results, energy levels, and how you feel overall.
Dosage: 200-400mg taken at night before bed.
Amazon pick: Doctor’s Best High Absorption Magnesium Glycinate – Third-party tested, chelated for maximum absorption, and consistently high-quality. This is the magnesium I personally take and recommend most often.
2. Electrolyte Mix (LMNT or Liquid I.V.) – Hydration That Actually Works
When you’re eating less food, you’re also getting significantly less water and sodium from meals. Add in potentially increased water intake (hopefully), and your electrolyte balance can get wonky fast. This shows up as fatigue, brain fog, headaches, dizziness, and worse nausea. Electrolytes aren’t just for athletes—they’re essential for basic cellular function, and they’re one of the simplest ways to feel dramatically better on supplements for GLP-1s.
Why it matters: Proper electrolyte balance supports hydration at the cellular level, reduces nausea, prevents the “GLP-1 fatigue” that leaves you dragging, and keeps your muscles and nervous system functioning properly. This is especially critical if you’re exercising or live in a hot climate.
How to use: Mix one packet into 16-20 oz of water, drink one in the morning and optionally one in the afternoon. This isn’t overkill—it’s addressing a real need that plain water doesn’t fix.
Amazon picks:
- LMNT Electrolyte Drink Mix – The gold standard. No sugar, science-backed sodium/potassium/magnesium ratios, flavors that don’t taste medicinal. The Citrus Salt and Watermelon Salt are chef’s kiss. Also comes in Raw Unflavored if you want to add it to anything without changing the taste.
- Liquid I.V. Hydration Multiplier – Slightly sweeter option with a bit of sugar for taste. The Passion Fruit and Strawberry flavors are solid. Great if LMNT’s saltiness is too intense for you.
3. Collagen Peptides or Whey Protein Isolate – Muscle Preservation is Non-Negotiable
Protein supplementation isn’t optional when you’re on GLP-1s—it’s essential. When you’re in a calorie deficit (which you definitely are), your body can break down muscle for energy if you’re not getting enough protein. Losing weight is great. Losing muscle mass while losing weight? That tanks your metabolism, makes you look “soft” instead of toned, and sets you up for weight regain later.
Why these two specifically: Collagen peptides are unflavored, dissolve in anything (coffee, tea, water, oatmeal), and provide 18-20g of protein per scoop. They also support skin elasticity (important during rapid weight loss), joint health, and gut lining integrity. Whey protein isolate is fast-absorbing, complete protein (all essential amino acids), and ideal post-workout or as a meal replacement when solid food sounds terrible.
Dosage: 1-2 scoops daily, bringing your total protein intake to 80-120g depending on your size and goals.
Amazon picks:
- Vital Proteins Collagen Peptides – Unflavored, dissolves completely, sourced from grass-fed cows. Mix it into literally anything for an easy 20g protein boost.
- Isopure Zero Carb Protein Powder – Whey isolate that mixes clear into water (wild, right?), 20g protein per serving, perfect for days when you need serious protein but can barely eat. Comes in fruity flavors that don’t taste like traditional protein powder.
4. Multivitamin with Iron – Your Nutrient Insurance Policy
A quality multivitamin fills the nutritional gaps that inevitably happen when you’re eating 1,000-1,400 calories daily. Even with the most nutrient-dense meal plan, you’re likely coming up short on several vitamins and minerals. A good multi provides baseline coverage for vitamins A, C, D, E, K, B-complex, zinc, selenium, and iron (especially important for menstruating women who are eating less red meat).
Why it matters: Micronutrient deficiencies tank your energy, weaken your immune system, affect your mood, and can stall your weight loss. A multivitamin isn’t a substitute for eating well, but it’s solid insurance when your food intake is limited.
What to look for: Third-party tested (NSF, USP, or ConsumerLab certified), includes iron if you’re a woman under 50, methylated B vitamins for better absorption, and doesn’t have megadoses of anything (more isn’t always better).
Amazon pick: Thorne Women’s Multi 50+ or Basic Nutrients 2/Day (depending on your age) – High-quality, clean ingredients, appropriate doses, no junk fillers. Thorne is the brand functional medicine practitioners consistently recommend. For men or those who don’t need iron, the Thorne Basic Nutrients 2/Day is excellent.
5. Vitamin B-Complex – Energy Production Support
B vitamins are directly involved in converting food into usable energy. When you’re eating less and potentially not getting enough B vitamins from food, supplementation helps maintain energy levels, mental clarity, and metabolism function. B12, B6, and folate are particularly important for energy, mood regulation, and nervous system support.
Why it matters: B vitamin deficiency mimics GLP-1 fatigue symptoms—exhaustion, brain fog, weakness, mood changes. Supplementing ensures you’re not dealing with unnecessary fatigue on top of your body’s adjustment to medication.
What to look for: Methylated forms (methylcobalamin for B12, methylfolate for folate) are better absorbed than synthetic forms. Take with food in the morning since B vitamins can be energizing.
Amazon pick: Thorne B-Complex #12 – Methylated forms for optimal absorption, well-balanced doses, no artificial colors or additives. One capsule daily with breakfast covers your bases.
6. Probiotic – Gut Health Support During Slower Digestion
GLP-1 medications slow your digestion significantly, which can disrupt your gut microbiome balance and lead to constipation, bloating, and general digestive discomfort. A quality probiotic supports digestive health, immune function (70% of your immune system lives in your gut), and can help with the regularity issues many people experience on tirzepatide supplements or semaglutide.
Why it matters: Your gut microbiome influences everything from digestion to mood to inflammation levels. Supporting it during metabolic changes helps reduce side effects and keeps your system functioning well.
What to look for: Multi-strain probiotic with at least 10 billion CFU, includes Lactobacillus and Bifidobacterium strains, shelf-stable or refrigerated depending on the brand.
Amazon pick: Garden of Life Dr. Formulated Probiotics for Women (or Men’s formula) – 50 billion CFU, 16 probiotic strains, includes prebiotics, shelf-stable. Take one daily with food. For a budget-friendly option, Culturelle Daily Probiotic is solid with Lactobacillus GG, a well-researched strain.
7. Omega-3 Fatty Acids (Fish Oil or Algae Oil) – Heart & Inflammation Support
Omega-3s support cardiovascular health, reduce inflammation, support joint health, and are crucial for brain function and mood regulation. When you’re eating less food (especially if you’re eating less fatty fish), you’re likely not getting enough omega-3s from diet alone. These essential fats are called “essential” for a reason—your body can’t make them, so you must get them from food or supplements.
Why it matters: Weight loss can be inflammatory for your body. Omega-3s help counteract that inflammation, support your heart health during metabolic changes, and can improve mood (important since weight loss journeys are emotional). They also support skin health and can help with the “loose skin” concerns some people have.
What to look for: At least 1,000mg combined EPA and DHA per serving, molecularly distilled (removes contaminants like mercury), and triglyceride form (better absorbed than ethyl ester form).
Amazon picks:
- Nordic Naturals Ultimate Omega – High-quality, great EPA/DHA ratio, lemon flavor minimizes fishy burps, third-party tested for purity. Take 2 softgels daily with food.
- Vegan option: Ora Organic Omega-3 DHA + EPA from Algae – If you’re plant-based or don’t want fish oil, algae-based omega-3s provide the same benefits. Sustainably sourced, no fishy taste.
Biohacker Bunny tip: If this feels like alphabet soup and you’re overwhelmed, don’t stress—just start with magnesium and protein. Those two make the biggest immediate impact. You can build your GLP-1 stack from there as you figure out what your body needs most. Not everyone needs all seven supplements, and that’s totally fine. Listen to your body and add what makes you feel noticeably better.
How to Stack Your Supplements for GLP-1s Safely
Having the best supplements for GLP-1s doesn’t help if taking them makes you feel worse or if you’re doubling up on things you don’t need. Here’s how to build your supplement routine without triggering nausea or creating problems:
Timing Matters for Absorption and Comfort
Take with food: Fat-soluble vitamins (A, D, E, K), omega-3s, and multivitamins absorb better with food and are less likely to cause nausea. Take these with breakfast or lunch.
Take at night: Magnesium glycinate works best before bed—it promotes relaxation and sleep. Taking it in the morning might make you drowsy.
Take on empty stomach or with light food: Probiotics are often most effective on an empty stomach or with a small amount of food. Follow your specific brand’s instructions.
Spread throughout the day: Don’t take all your supplements in one go. This can overwhelm your stomach (especially on GLP-1s) and reduce absorption. Morning batch with breakfast, afternoon protein/electrolytes, evening magnesium works well.
What to Avoid Doubling Up On
Iron: If your multivitamin includes iron, don’t add a separate iron supplement unless your doctor has confirmed you’re deficient through bloodwork. Too much iron causes constipation and nausea—exactly what you don’t need on semaglutide.
B vitamins: One B-complex OR a multivitamin with B vitamins is enough. Taking both is unnecessary and can cause side effects like flushed skin or digestive upset.
Fat-soluble vitamins: Don’t mega-dose on vitamins A, D, E, or K—they accumulate in your body and can reach toxic levels. Stick to recommended doses.
Stacking with Peptides (For the Advanced Biohackers)
If you’re working with a telehealth provider like GobyMeds or OrderlyMeds and stacking GLP-1s with other peptides (like NAD+ or sermorelin), your supplement needs might be slightly different. Peptides for recovery and longevity work synergistically with GLP-1s, but you want to ensure your basics are covered first.
The foundation stays the same: Magnesium, protein, electrolytes, and a multivitamin support any peptide stack. These cover your bases regardless of what else you’re adding.
Additional considerations: If you’re using peptides that support tissue repair or muscle growth, you might benefit from higher protein intake and potentially adding creatine monohydrate (5g daily). If you’re using NAD+ or NAD+ precursors, B vitamins become even more important.
Check with your provider: Always loop in your prescribing provider about your supplement routine, especially if you’re stacking multiple treatments. They can help you optimize timing and avoid any potential interactions.
Want to learn more about peptide stacking? Check out my Beginner’s Guide to NAD & Sermorelin Peptides for the full breakdown on how these work with GLP-1s.
Organization Helps Consistency
Let’s be honest—you’re not going to take supplements for GLP-1s consistently if you’re fishing through 7 different bottles every day. Invest in a weekly pill organizer or supplement travel case that keeps everything sorted and visible.
Amazon picks for organization:
- MEDca Weekly Pill Organizer – Four compartments per day, large enough for multiple supplements, see-through so you know what you’ve taken. Makes it impossible to forget doses.
- BEXEEN Supplement Organizer Travel Case – Compact, portable, perfect for keeping your daily supplements together whether at home or traveling. Fits in a purse or gym bag.
Set up your supplements for the week every Sunday. Make it a non-negotiable ritual like meal prep. When taking your supplements is easy and visible, you’ll actually do it consistently—and consistency is what creates results.
Start Small, Stay Consistent, Remember Your Why
Here’s the truth about supplements for GLP-1s: they’re not shortcuts, they’re sidekicks. They work with your medication and healthy habits, not instead of them. The magic isn’t in any single supplement—it’s in the consistency of supporting your body day after day while it’s navigating significant metabolic changes. You’re asking your body to do something hard (lose weight while maintaining muscle, energy, and health), so give it the tools it needs to succeed.
Start with the basics—magnesium, protein, and electrolytes. These three make the most immediate difference in how you feel. Add the others as your budget and routine allow. Not everyone needs all seven, and that’s completely fine. Pay attention to how you feel, track what makes a difference, and adjust accordingly. Your optimal GLP-1 vitamins stack might look different than someone else’s, and that’s expected.
Ready to build your complete GLP-1 support system? Check out The Ultimate GLP-1 Starter Kit for all the accessories and essentials that pair perfectly with these supplements.
Dealing with nausea that makes taking supplements difficult? My post Nausea on GLP-1s? What Works has strategies for keeping supplements (and everything else) down when your stomach is being difficult.
Exploring peptide stacking for advanced results? Head over to Beginner’s Guide to NAD & Sermorelin Peptides to understand how these compounds work synergistically with GLP-1s for metabolic optimization and longevity.
Now it’s your turn: What supplements have made the biggest difference in your GLP-1 journey? Drop a comment below with your must-haves or questions about building your stack. This community is gold, and sharing what’s actually working helps everyone level up their game.
Remember—you’re not just taking supplements for GLP-1s. You’re investing in feeling good, having energy, preserving your health, and making this weight loss journey sustainable instead of something you’re white-knuckling through with sheer willpower. That’s the difference between short-term results and long-term transformation. You’ve got this, bestie. 🐰✨
DISCLAIMER: Some links on this site are affiliate links, which means we might earn a small commission if you shop through them (no extra cost to you—think of it as buying us a matcha 🍵 for the research).
While some of us are doctors, we’re not your doctors. The info on this site is meant to educate and empower, not diagnose or treat. Always chat with your own healthcare provider before starting new meds, peptides, supplements, or that intense cold plunge-fasting-stack we’re raving about. You do you—but do it safely. 💪
